Cardiovascular Disease

Carbazeran citrate is a phosphodiesterase inhibitor. Carbazeran citrate is oxidized by aldehyde oxidase/AOX1 to 4-oxo-Carbazeran citrate/hydroxyCarbazeran citrate, serving as an AOX1 probe and competitively inhibiting xanthine oxidase. Carbazeran citrate can be used in research on congestive heart failure and chronic heart failure.

NADH disodium hydrate (Disodium NADH hydrate) is an orally effective reduced coenzyme. NADH disodium hydrate plays a role in regenerating electron donors during cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle. NADH disodium hydrate regulates calcium homeostasis by promoting the opening of IP3-gated Ca²⁺ channels and inhibiting Ryanodine receptor, and affects mitochondrial function through direct interaction with VDAC. NADH disodium hydrate is used in cytoprotective studies related to cerebral ischemic injury, neurodegenerative diseases, aging, and signal transduction.

Furosemide solution is mainly composed of Furosemide (HY-B0135). Furosemide is a potent and orally active inhibitor of Na⁺/K⁺/2Cl^- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide is also a GABA_A receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema.

JNJ 303-d₃ is the deuterium labeled JNJ 303 (HY-16953). JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC₅₀ value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system.

ACLY-IN-1 is an orally active ACLY inhibitor. ACLY-IN-1 exhibits potent ACLY inhibitory activity (IC₅₀ = 8.3 nM) and high binding affinity (K_D = 72.0 nM) to ACLY. ACLY-IN-1 demonstrates good pharmacokinetic profiles and a potent in vivo hypolipidemic effect.

BRD1172 (ML320) is a selectivity GSK3β inhibitor with an IC₅₀ of 24 nM for GSK3β over CDK5. BRD1172 significantly inhibits GSK3β-mediated Tau phosphorylation in SH-SY5Y cells, and relieves negative regulation by GSK3β on β-catenin degradation and TCF/LEF promoter activities. BRD1172 can be used for Alzheimer’s disease, cardiac hypertrophy and cancers research.

LY-272015 is an orally active, specific 5-HT_2B receptor antagonist. LY-272015 completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats.

Oberadilol (CID-3047798) is a Phosphodiesterase III inhibitor, non-selective β-adrenergic receptor blocker, vasodilator and positive inotropic agent. Oberadilol reduces left ventricular end-diastolic volume. Oberadilol is used in research related to chronic congestive heart failure and SARS-CoV-2 infection.

Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca²⁺-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits P-selectin and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders.

XR 5118 hydrochloride is an inhibitor of plasminogen activator inhibitor 1 (PAI-1) (IC₅₀: 12 µM). XR5118 binds to PAI-1 and reduces plasma PAI-1 activity levels. XR5118 hydrochloride promotes endogenous thrombolysis and inhibits thrombus accretion. XR 5118 hydrochloride can be used for research of cancer and thrombotic disease.

LacCer(d18:1/24:0) is a lipid. LacCer(d18:1/24:0) can be found in plasma. LacCer(d18:1/24:0) is associated with critical illness after cardiac surgery.

4H-Tomentosin is a mixed-competitive type soluble epoxide hydrolase (sEH) inhibitor with an IC₅₀ of 6.84 μM and a K_i of 7.02 μM. 4H-Tomentosin interacts with sEH by forming hydrogen bonds with Tyr343, Ile363, and Tyr383.

Biciromab is a anti-human monoclonal antibody targeting FGB/Fibrinogen beta chain.

Bucumolol hydrochloride is a β-adrenergic receptor antagonist that can slow heart rate (negative chronotropic effect) and reduce cardiac contractility (negative inotropic effect). Bucumolol hydrochloride has antiarrhythmic and local anesthetic activity and can be used in the study of cardiovascular diseases.

Inclisiran sodium scrambled negative control is the sequence scrambled negative control of Inclisiran sodium.

Himbacine ((+)-Himbacine) is a potent antihypertensive agent. Himbacine decreases in both mean blood pressure and heart rate.

Vin-C01 is a potent pancreatic β-cells protective agent with an EC₅₀ of 0.22 μM. Vin-C01 effectively promotes β-cell survival and protects β-cells from STZ (HY-13753)-induced apoptosis. Vin-C01 can be used for type 2 diabetes mellitus research.

NE-10133 is a I_SK and I_KS potassium channel (Potassium Channel) inhibitor. NE-10133 inhibits voltage-dependent and slowly activated delayed rectifier potassium currents. NE-10133 exhibits class III antiarrhythmic activity. NE-10133 is applicable for research related to arrhythmias.

RXFP1 receptor agonist-8 (Example 2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-8 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 1.8 nM.

α1b-AR antagonist 1 (Compound Cpd1) is a selective α₁B-AR antagonist. Alpha1b-ar antagonist 1 can be used in the study of cardiovascular and central nervous system diseases.